After looking at some pictures it appears the our hops were not yet ripe or were Japanese hops, an invasive non-native plant that is not used in beer making. One plant produced 1000+ cones while the other two of another variety barely survived. The vines were cut yesterday and will be picked this weekend if we decide to keep the cones. The yellowing is probably an endophytic phytopathogen from either the verticillium or fusarium fungi families. The spotting is called chlorosis and is common to see with wilt fungi. Only way to control it is good garden sanitation.
– Richard Gardner